Reliable and high analytical performance results
with correct estimation of FLC values without antigen excess or overestimation by polymerization vs Nephelometry / Turbidimetry Methods.
About FLC
- Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ).
- The quantification of serum FLC is used as an aid in the diagnosis and monitoring patients with Multiple Myeloma.
- Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges may indicate presence of plasma cell disorders disease like Multiple Myeloma or AL amyloidosis in a patient.
- Nephelometric and turbidimetric based assays have been shown to overestimate the sFLC levels that are not always consistent with Serum Protein Electrophoresis/Immunofixation and other clinical parameters.
Related Pathologies
Technologies used
Key benefits
A trusted and cost-effective FLC solution with strong, proven performance, delivering highly reliable results essential across the entire the multiple myeloma patient journey.
Trust in the results
with concordance value between SPE and FLC Kappa & FLC Lambda which help on interpretation results.
Follow IMWG guidelines
"20" and "100" FLC ratio cut-points can be used with Sebia FLC assays, for an appropriate patient management and easier implementation in the laboratory.
4 times lower retest rates
vs other methods and lower manual dilutions needed.
Easily adapted and scalable
to any type of ELISA Instrument for standardization and efficiency process.
Clinical performance
96.8% concordance based on the IMWG Criteria for the Diagnosis of MM
Main characteristics
Test principle
Quantification of Kappa or Lambda Free Light Chains is performed with an Enzyme-Linked Immunosorbent Assay (ELISA) procedure utilizing specific antibodies anti-Kappa or anti-Lambda free light chains.
Sample type
Serum
Product details
Microplate with 96 wells in strip format.
- FLC Kappa – P/N: 5102
- FLC Lambda – P/N: 5103
- FLC Control Level 1 – P/N: 5112
- FLC Control Level 2 – P/N: 5113
Knowledge & Science
We offer daily assistance for technical and scientific matters.
We aim to educate and share scientific and medical educational information with our customers all around the world.
Understand in 2 minutes how capillary electrophoresis works, and why it gives such high and clear resolution in lab testing.
FLC test can be performed on the following instrument
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Capillary Electrophoresis solution to meet your high capacity needs.
High Throughput - Smart Automation.
A concentrate of Sebia’s expertise in a high throughput instrument.
Tests related to FLC
This section contains information intended for wide distribution and may therefore contain product details or information that is not available or valid in your country. Please contact your local Sebia representative. Information intended for healthcare professionals. Carefully read the instructions in the reagent package inserts and instrument manuals.